The fecal alpha-1-protease inhibitor activity test is a newly developed assay to assist in the diagnosis of protein-losing enteropathies (such as IBD, intestinal lymphoma, lymphangiectasia, and histoplasmosis). Alpha-1-protease inhibitor is a serum protein that leaks into the intestinal lumen of animals with protein-losing enteropathies, and can be detected in the feces because it resists degradation by fecal proteases. This test is very sensitive for detecting protein-losing enteropathies, and will detect disease before protein loss is severe enough to cause hypoalbuminemia or panhypoproteinemia. The test is species-specific and is only available for dogs at this time.